MicroRNA in Cancer Prognosis

Abstract

Ovarian cancer is the leading cause of deaths from gynecologic cancer, and although there are nomograms that use pathological variables to predict outcome for advanced-stage disease,¹ few if any molecular mechanisms that accurately predict outcome and can potentially guide therapy have been identified. The article by Merritt et al.² in this issue of the Journal provides evidence for a simple mechanism, based on the biologic characteristics of microRNAs (miRNAs), for formulating a prognosis and potentially guiding therapy in ovarian cancer.The past decade has heralded in a new era in the understanding of gene regulation in diseases such as cancer. . . .