Role of macrophages in the progression of acute pancreatitis
Open Access
- 1 January 2010
- journal article
- Published by Baishideng Publishing Group Inc. in World Journal of Gastrointestinal Pharmacology and Therapeutics
- Vol. 1 (5), 107-111
- https://doi.org/10.4292/wjgpt.v1.i5.107
Abstract
In addition to pancreatic cells, other inflammatory cell populations contribute to the generation of inflammatory mediators during acute pancreatitis. In particular, macrophages could be activated by mediators released during pancreatitis by a damaged pancreas. It has been reported that peritoneal macrophages, alveolar macrophages and Kupffer cells become activated in different stages of severe acute pancreatitis. However, macrophages display remarkable plasticity and can change their physiology in response to environmental cues. Depending on their microenvironmental stimulation, macrophages could follow different activation pathways resulting in marked phenotypic heterogeneity. This ability has made these cells interesting therapeutical targets and several approaches have been assayed to modulate the progression of inflammatory response secondary to acute pancreatitis. However, despite the recent advances in the modulation of macrophage function in vivo, the therapeutical applications of these strategies require a better understanding of the regulation of gene expression in these cells.Keywords
This publication has 47 references indexed in Scilit:
- In vitro, but not in vivo, reversibility of peritoneal macrophages activation during experimental acute pancreatitisBMC Immunology, 2009
- Exploring the full spectrum of macrophage activationNature Reviews Immunology, 2008
- Biochemical and functional characterization of three activated macrophage populationsJournal of Leukocyte Biology, 2006
- Macrophage ablation attenuates adenoviral vector–induced pancreatitisSurgery, 2005
- Proinflammatory effects of pancreatic elastase are mediated through TLR4 and NF-κBBiochemical and Biophysical Research Communications, 2004
- Alternative activation of macrophagesNature Reviews Immunology, 2003
- Nitric Oxide Is Overproduced by Peritoneal Macrophages in Rat Taurocholate PancreatitisPancreas, 1998
- Macrophage pacification reduces rodent pancreatitis-induced hepatocellular injury through down-regulation of hepatic tumor necrosis factor ? and interleukin-1?Journal of Hepatology, 1998
- Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.JCI Insight, 1998
- Interleukin 4 potently enhances murine macrophage mannose receptor activity: a marker of alternative immunologic macrophage activation.The Journal of Experimental Medicine, 1992