Heart failure as an endpoint in heart failure and non-heart failure cardiovascular clinical trials: the need for a consensus definition
Open Access
- 1 February 2008
- journal article
- research article
- Published by Oxford University Press (OUP) in European Heart Journal
- Vol. 29 (3), 413-421
- https://doi.org/10.1093/eurheartj/ehm603
Abstract
Specific criteria have been established to define the occurrence of myocardial infarction (MI) and stroke in cardiovascular clinical trials, but there is not a consistent definition for heart failure. Heart failure events appear to occur at a rate that is similar to stroke and MI in trials of hypertension, hyperlipidaemia, diabetes, and coronary heart disease, yet a consistent approach to defining heart failure events has not yet been realized. The wide range of definitions used in clinical trials makes it difficult to interpret new data in the context of existing literature. This inconsistency has led to challenges in determining the incidence of heart failure in cardiovascular studies and the effects of interventions on these endpoints. This paper examines issues related to defining heart failure events in cardiovascular clinical trials and presents a definition to formally address this issue.Keywords
This publication has 60 references indexed in Scilit:
- Universal Definition of Myocardial InfarctionCirculation, 2007
- Abdominal Obesity Is an Independent Risk Factor for Chronic Heart Failure in Older PeopleJournal of the American Geriatrics Society, 2006
- Heart Disease and Stroke Statistics—2006 UpdateCirculation, 2006
- Metabolic Syndrome and Risk of Cardiovascular Events After Myocardial InfarctionJournal of the American College of Cardiology, 2005
- Characteristics and outcomes of patients hospitalized for heart failure in the United States: Rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE)American Heart Journal, 2005
- Predictors of Heart Failure Among Women With Coronary DiseaseCirculation, 2004
- Progressing Stroke: Towards an Internationally Agreed DefinitionCerebrovascular Diseases, 2003
- Predictors of congestive heart failure in the elderly: the cardiovascular health studyJournal of the American College of Cardiology, 2000
- Moving toward a new definition of acute myocardial infarction for the 21st century: Status of the ESC/ACC Consensus ConferenceJournal of Electrocardiology, 2000
- Has the survival of the heart failure population changed? lessons from trialsThe American Journal of Cardiology, 1999