Diffusion Abnormalities and Reduced Volume of the Ventral Cingulum Bundle in Agenesis of the Corpus Callosum: A 3T Imaging Study
Open Access
- 26 February 2009
- journal article
- Published by American Society of Neuroradiology (ASNR) in American Journal Of Neuroradiology
- Vol. 30 (6), 1142-1148
- https://doi.org/10.3174/ajnr.a1527
Abstract
BACKGROUND AND PURPOSE: Patients with agenesis of the corpus callosum (AgCC) exhibit cognitive and behavioral impairments that are not replicated by surgical transection of the callosum, suggesting that other anatomic changes may contribute to the observed clinical findings. The purpose of this study was to determine whether the ventral cingulum bundle (VCB) is affected in patients with AgCC by using diffusion tensor imaging (DTI) and volumetry. MATERIALS AND METHODS: Twelve participants with AgCC (8 males and 4 females; mean age, 30 ± 20) and 12 control subjects matched for age and sex (mean age, 37 ± 19) underwent MR imaging and DTI at 3T. 3D fiber tracking of the VCB was generated from DTI and the average fractional anisotropy (FA) was computed for the tracked fibers. Additionally, the volume, cross-sectional area, and length of the VCB were measured by manually drawn regions of interest on thin-section coronal T1-weighted images. The Student t test was used to compare these results. RESULTS: Compared with controls, subjects with AgCC demonstrated significantly reduced FA in the right VCB (P = .0098) and reduced volume and cross-sectional areas of both the left and right VCB (P < .001 for all metrics). The length of the VCB was also significantly reduced in the complete AgCC subgroup compared with controls (P = .030 in the right and P = .046 in the left, respectively). CONCLUSIONS: Patients with AgCC have abnormal microstructure and reduced volume of the VCB, suggesting that abnormalities in intrahemispheric white matter tracts may be an important contributor to the clinical syndrome in patients with AgCC.Keywords
This publication has 46 references indexed in Scilit:
- Bilateral frontoparietal polymicrogyria, Lennox‐Gastaut syndrome, and GPR56 gene mutationsEpilepsia, 2009
- Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imagingThe British Journal of Psychiatry, 2008
- Agenesis of the corpus callosum in California 1983–2003: A population‐based studyAmerican Journal of Medical Genetics Part A, 2008
- Effects of diffusion weighting schemes on the reproducibility of DTI-derived fractional anisotropy, mean diffusivity, and principal eigenvector measurements at 1.5TNeuroImage, 2007
- A case of schizophrenia with complete agenesis of the corpus callosumAustralasian Psychiatry, 2006
- Neuroplasticity in Human Callosal Dysgenesis: A Diffusion Tensor Imaging StudyCerebral Cortex, 2006
- Imaging, anatomical, and molecular analysis of callosal formation in the developing human fetal brainThe Anatomical Record Part A: Discoveries in Molecular, Cellular, and Evolutionary Biology, 2006
- MRI study of white matter diffusion anisotropy in schizophreniaNeuroReport, 2003
- Trends in elective terminations of pregnancy between 1989 and 2000 in a French county (the Isère)Prenatal Diagnosis, 2003
- Monozygotic twin cases of the agenesis of the corpus callosum with schizophrenic disorderPsychiatry and Clinical Neurosciences, 2002