Gene-targeting studies of mammalian behavior: is it the mutation or the background genotype?
- 1 May 1996
- journal article
- Published by Elsevier BV in Trends in Neurosciences
- Vol. 19 (5), 177-181
- https://doi.org/10.1016/s0166-2236(96)20020-7
Abstract
Gene targeting to create null mutations in mice is a powerful new tool in biology which will allow the molecular dissection of complex phenotypes such as mammalian brain function, and learning and memory. However, the attempt to interpret the phenotypical changes which arise in null-mutant mice is subject to several caveats. For example, the ability to disrupt a single gene in a targeted manner might lead one to overlook the effects of other genes. Ignoring the genetic background might lead to misinterpretation of results: the present article will demonstrate that the phenotypical abnormalities attributed to the null mutation in several molecular neurobiological studies could simply result from the effects of background genes.Keywords
This publication has 20 references indexed in Scilit:
- Impaired motor learning performance in cerebellar En-2 mutant mice.Behavioral Neuroscience, 1996
- Strain-Dependent Epithelial Defects in Mice Lacking the EGF ReceptorScience, 1995
- The secretory phospholipase A2 gene is a candidate for the Mom1 locus, a major modifier of ApcMin-induced intestinal neoplasiaCell, 1995
- Impairment of motor coordination, Purkinje cell synapse formation, and cerebellar long-term depression in GluRδ2 mutant miceCell, 1995
- Knockout mouse fault linesNature, 1995
- Abnormal avoidance learning in mice lacking functional high-affinity nicotine receptor in the brainNature, 1995
- Enhanced Aggressive Behavior in Mice Lacking 5-HT 1B ReceptorScience, 1994
- Inactivation of the N-CAM gene in mice results in size reduction of the olfactory bulb and deficits in spatial learningNature, 1994
- The Pierian SpringCurrent Biology, 1992
- Impaired Spatial Learning in α-Calcium-Calmodulin Kinase II Mutant MiceScience, 1992