Peripheral-T-Cell Lymphoma with Hemophagocytic Histiocytosis Localised to the Bone Marrow Associated with Inappropriate Secretion of Antidiuretic Hormone
- 1 January 1995
- journal article
- case report
- Published by Informa UK Limited in Leukemia & Lymphoma
- Vol. 19 (5-6), 511-514
- https://doi.org/10.3109/10428199509112213
Abstract
A patient with high fever, loss of weight and profound pancytopenia is reported. Peripheral T-cell lymphoma with hemophagocytosis was diagnosed. Bone marrow was the only localisation of the lymphoma. At presentation there were (i) a coagulopathy consistent with hemophagocytic histiocytosis (ii) the features of the syndrome of inappropriate antidiuretic hormone secretion (SIADH). These different abnormalities disappeared after chemotherapy and reappeared during each of the 2 periods of disease progression. The patient died 6 months after diagnosis without ever achieving complete remission. As far as we are aware this is the first case report of T-cell lymphoma with hemophagocytic syndrome localised to the bone marrow and associated with SIADH.Keywords
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