B cell-regulated immune responses in tumor models and cancer patients
Open Access
- 1 July 2013
- journal article
- Published by Informa UK Limited in OncoImmunology
- Vol. 2 (7), e25443
- https://doi.org/10.4161/onci.25443
Abstract
The essential role played by T cells in anticancer immunity is widely accepted. The immunosuppressive functions of regulatory T cells are central for tumor progression and have been endowed with a robust predictive value. Increasing evidence indicates that also B cells have a crucial part in the regulation of T-cell responses against tumors. Although experiments reporting the production of natural antitumor antibodies and the induction of cytotoxic immune responses have revealed a tumor-protective function for B cells, other findings suggest that B cells may also exert tumor-promoting functions, resulting in a controversial picture. Here, we review recent evidence on the interactions between B and T cells in murine models and cancer patients and their implications for cancer immunology.Keywords
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