TriggeringAkkermansiawith dietary polyphenols: A new weapon to combat the metabolic syndrome?
Open Access
- 22 February 2016
- journal article
- editorial
- Published by Informa UK Limited in Gut Microbes
- Vol. 7 (2), 146-153
- https://doi.org/10.1080/19490976.2016.1142036
Abstract
The gut and its bacterial colonizers are now well characterized as key players in whole-body metabolism, opening new avenues of research and generating great expectation for new treatments against obesity and its cardiometabolic complications. As diet is the main environmental factor affecting the gut microbiota, it has been suggested that fruits and vegetables, whose consumption is strongly associated with a healthy lifestyle, may carry phytochemicals that could help maintain intestinal homeostasis and metabolic health. We recently demonstrated that oral administration of a cranberry extract rich in polyphenols prevented diet-induced obesity and several detrimental features of the metabolic syndrome in association with a remarkable increase in the abundance of the mucin-degrading bacterium Akkermansia in the gut microbiota of mice. This addendum provides an extended discussion in light of recent discoveries suggesting a mechanistic link between polyphenols and Akkermansia, also contemplating how this unique microorganism may be exploited to fight the metabolic syndrome.Keywords
This publication has 56 references indexed in Scilit:
- Extracellular Vesicles Derived from Gut Microbiota, Especially Akkermansia muciniphila, Protect the Progression of Dextran Sulfate Sodium-Induced ColitisPLOS ONE, 2013
- Commensal Akkermansia muciniphila Exacerbates Gut Inflammation in Salmonella Typhimurium-Infected Gnotobiotic MicePLOS ONE, 2013
- Cross-talk between Akkermansia muciniphila and intestinal epithelium controls diet-induced obesityProceedings of the National Academy of Sciences of the United States of America, 2013
- Gram-negative bacteria account for main differences between faecal microbiota from patients with ulcerative colitis and healthy controlsBeneficial Microbes, 2012
- Intestinal Inflammation Targets Cancer-Inducing Activity of the MicrobiotaScience, 2012
- Inflammasome-mediated dysbiosis regulates progression of NAFLD and obesityNature, 2012
- Nod-like receptor pyrin domain-containing protein 6 (NLRP6) controls epithelial self-renewal and colorectal carcinogenesis upon injuryProceedings of the National Academy of Sciences of the United States of America, 2011
- Importance and regulation of the colonic mucus barrier in a mouse model of colitisAmerican Journal of Physiology-Gastrointestinal and Liver Physiology, 2011
- Xenohormesis: Sensing the Chemical Cues of Other SpeciesCell, 2008
- Cranberry Products Inhibit Adherence of P-Fimbriated Escherichia Coli to Primary Cultured Bladder and Vaginal Epithelial CellsJournal of Urology, 2007