Extensive Duplication and Reshuffling in the Arabidopsis Genome
Open Access
- 1 July 2000
- journal article
- Published by Oxford University Press (OUP) in Plant Cell
- Vol. 12 (7), 1093-1101
- https://doi.org/10.1105/tpc.12.7.1093
Abstract
Systematic analysis of the Arabidopsis genome provides a basis for detailed studies of genome structure and evolution. Members of multigene families were mapped, and random sequence alignment was used to identify regions of extended similarity in the Arabidopsis genome. Detailed analysis showed that the number, order, and orientation of genes were conserved over large regions of the genome, revealing extensive duplication covering the majority of the known genomic sequence. Fine mapping analysis showed much rearrangement, resulting in a patchwork of duplicated regions that indicated deletion, insertion, tandem duplication, inversion, and reciprocal translocation. The implications of these observations for evolution of the Arabidopsis genome as well as their usefulness for analysis and annotation of the genomic sequence and in comparative genomics are discussed.Keywords
This publication has 30 references indexed in Scilit:
- Sequence and analysis of chromosome 2 of the plant Arabidopsis thalianaNature, 1999
- Sequence and analysis of chromosome 4 of the plant Arabidopsis thalianaNature, 1999
- Eukaryote genome duplication - where's the evidence?Current Opinion in Genetics & Development, 1998
- Plant Comparative Genetics after 10 YearsScience, 1998
- To pair or not to pair: chromosome pairing and evolutionCurrent Opinion in Plant Biology, 1998
- Comparative sequence analysis of a gene-rich cluster at human chromosome 12p13 and its syntenic region in mouse chromosome 6.1998
- Molecular evidence for an ancient duplication of the entire yeast genomeNature, 1997
- Two‐dimensional RFLP analyses reveal megabase‐sized clusters of rRNA gene variants in Arabidopsis thaliana, suggesting local spreading of variants as the mode for gene homogenization during concerted evolutionThe Plant Journal, 1996
- Duplicate sequences with a similarity to expressed genes in the genome of Arabidopsis thalianaTheoretical and Applied Genetics, 1993
- Structure and expression of kin2, one of two cold- and ABA-induced genes of Arabidopsis thalianaPlant Molecular Biology, 1992