Preservation of lower incidence of chronic lymphocytic leukemia in Chinese residents in British Columbia: a 26-year survey from 1983 to 2008
- 12 September 2013
- journal article
- review article
- Published by Taylor & Francis Ltd in Leukemia & Lymphoma
- Vol. 55 (4), 824-827
- https://doi.org/10.3109/10428194.2013.827785
Abstract
The incidence of chronic lymphocytic leukemia (CLL) in the Asian population is up to 10 times lower than that in Caucasians. Studies on CLL in Asian residents in North America may help to determine the relative genetic and environmental causes of such a difference. Computerized records of CLL incidence from the combined British Columbia (BC) databases (n = 2736) and the Hong Kong Cancer Registry (HKCR, n = 572) were traced. Ethnic Chinese cases of CLL in BC were identified (n = 35). The world age standardized rates (WASRs) of CLL (per 100 000) were calculated in BC (1.71), HK (0.28) and BC Chinese (0.4), respectively. Using standard incidence ratios (SIRs), the observed BC Chinese case number was comparable to the figure projected from HK rates (SIR 1.3, p = 0.1) but significantly lower than the figure following BC rates (SIR 0.22, p < 0.0001). The difference was maintained over both genders, in all age groups and through the years. Our data over three decades suggest that genetic factors outplay environmental factors to give lower CLL rates in Chinese.This publication has 25 references indexed in Scilit:
- Allogeneic haematopoietic stem cell transplantation for chronic lymphocytic leukaemia: outcome in a 20‐year cohortBritish Journal of Haematology, 2012
- Lower incidence of plasma cell neoplasm is maintained in migrant Chinese to British Columbia: findings from a 30-year surveyLeukemia & Lymphoma, 2011
- The incidence of chronic lymphocytic leukemia in Taiwan, 1986-2005: a distinct increasing trend with birth-cohort effectBlood, 2010
- Single nucleotide polymorphisms of matrix metalloproteinase 9 (MMP9) and tumor protein 73 (TP73) interact with Epstein-Barr virus in chronic lymphocytic leukemia: results from the European case-control study EpiLymphHaematologica, 2010
- Chronic lymphocytic leukaemia and small lymphocytic lymphoma: overview of the descriptive epidemiologyBritish Journal of Haematology, 2007
- Chronic lymphocytic leukaemia: an overview of aetiology in light of recent developments in classification and pathogenesisBritish Journal of Haematology, 2007
- Familial CLL: Genes and EnvironmentHematology, 2007
- Incidence and spectrum of non‐Hodgkin lymphoma in Chinese migrants to British ColumbiaBritish Journal of Haematology, 2005
- The clinical and epidemiological burden of chronic lymphocytic leukaemiaEuropean Journal of Cancer Care, 2004
- Hodgkin’s lymphoma in Chinese migrants to British Columbia:a 25-year surveyAnnals of Oncology, 2004