The New Neurobiology of Autism
- 1 July 2007
- journal article
- review article
- Published by American Medical Association (AMA) in Archives of Neurology
- Vol. 64 (7), 945-950
- https://doi.org/10.1001/archneur.64.7.945
Abstract
This review covers a fraction of the new research developments in autism but establishes the basic elements of the new neurobiologic understanding of autism. Autism is a polygenetic developmental neurobiologic disorder with multiorgan system involvement, though it predominantly involves central nervous system dysfunction. The evidence supports autism as a disorder of the association cortex, both its neurons and their projections. In particular, it is a disorder of connectivity, which appears, from current evidence, to primarily involve intrahemispheric connectivity. The focus of connectivity studies thus far has been on white matter, but alterations in functional magnetic resonance imaging activation suggest that intracortical connectivity is also likely to be disturbed. Furthermore, the disorder has a broad impact on cognitive and neurologic functioning. Deficits in high-functioning individuals occur in processing that places high demands on integration of information and coordination of multiple neural systems. Intact or enhanced abilities share a dependence on low information-processing demands and local neural connections. This multidomain model with shared characteristics predicts an underlying pathophysiologic mechanism that impacts the brain broadly, according to a common neurobiologic principle. The multiorgan system involvement and diversity of central nervous system findings suggest an epigenetic mechanism.Keywords
This publication has 30 references indexed in Scilit:
- A genetic variant that disrupts MET transcription is associated with autismProceedings of the National Academy of Sciences of the United States of America, 2006
- Head circumference and height in autism: A study by the collaborative program of excellence in autismAmerican Journal of Medical Genetics Part A, 2006
- Neuropsychologic Functioning in Children with Autism: Further Evidence for Disordered Complex Information-ProcessingChild Neuropsychology, 2006
- Sentence comprehension in autism: thinking in pictures with decreased functional connectivityBrain, 2006
- Functional and Anatomical Cortical Underconnectivity in Autism: Evidence from an fMRI Study of an Executive Function Task and Corpus Callosum MorphometryCerebral Cortex, 2006
- Advances in autism neuroimaging research for the clinician and geneticistSeminars in Medical Genetics, Part C of the American Journal of Medical Genetics, 2006
- Understanding emotions in others: mirror neuron dysfunction in children with autism spectrum disordersNature Neuroscience, 2005
- Disruption of Interneuron DevelopmentEpilepsia, 2005
- Cortical activation and synchronization during sentence comprehension in high-functioning autism: evidence of underconnectivityBrain, 2004
- Abstract reasoning in autism: A disassociation between concept formation and concept identification.Neuropsychology, 2002