Granulocyte Colony-Stimulating Factor: A Novel Mediator of T Cell Tolerance
- 1 December 2005
- journal article
- review article
- Published by The American Association of Immunologists in The Journal of Immunology
- Vol. 175 (11), 7085-7091
- https://doi.org/10.4049/jimmunol.175.11.7085
Abstract
In recent years, several investigators have unraveled a previously unrecognized role for G-CSF in the regulation of T cell and dendritic cell functions. The experimental evidence in favor of G-CSF-mediated immune regulation includes the ability to switch T cell cytokine secretion profile to Th2 responses and the promotion of regulatory T cell and tolerogenic dendritic cell differentiation. Interestingly, G-CSF is beneficial in animals for the prevention and/or treatment of immune-mediated diseases, e.g., graft-vs-host disease, multiple sclerosis, systemic lupus erythematosus, inflammatory bowel disease, and diabetes, suggesting a potential role in human autoimmune diseases. This review summarizes the growing body of evidence that supports a critical role for G-CSF as a novel mediator of T cell tolerance.Keywords
This publication has 76 references indexed in Scilit:
- Granulocyte and granulocyte-macrophage colony-stimulating factors in allografts: Uses, misuses, misconceptions, and future applicationsExperimental Hematology, 2005
- Graft-versus-host-disease and granulocyte colony-stimulating factor administration after allogeneic stem cell transplantationLeukemia, 2005
- Mechanisms and functional significance of tumour-induced dendritic-cell defectsNature Reviews Immunology, 2004
- Donor treatment with pegylated G-CSF augments the generation of IL-10-producing regulatory T cells and promotes transplantation toleranceBlood, 2004
- Treatment With Granulocyte Colony-Stimulating Factor After Allogeneic Bone Marrow Transplantation for Acute Leukemia Increases the Risk of Graft-Versus-Host Disease and Death: A Study From the Acute Leukemia Working Party of the European Group for Blood and Marrow TransplantationJournal of Clinical Oncology, 2004
- Use of Granulocyte Colony-Stimulating Factor Following Hematopoietic Cell Transplantation: Does Haste Make Waste?Journal of Clinical Oncology, 2004
- The effect of hematopoietic growth factors on the risk of graft-vs-host disease after allogeneic hematopoietic stem cell transplantation: a meta-analysisBone Marrow Transplantation, 2003
- Regulation of T helper type-1 immunity in hapten-induced colitis by host pretreatment with granulocyte colony-stimulating factor☆Cytokine, 2003
- Granulocyte-colony stimulating factor increases CD123hi blood dendritic cells with altered CD62L and CCR7 expressionBlood, 2003
- Alloantigen presenting capacity, T cell alloreactivity and NK function of G-CSF-mobilized peripheral blood cellsBone Marrow Transplantation, 1998