Differential effects of 6-hydroxydopamine on the two types of nerve vesicles and dopamine and noradrenaline content in mesenteric arterial vessels
- 1 March 1988
- journal article
- Published by Wiley in Journal of Autonomic Pharmacology
- Vol. 8 (1), 1-10
- https://doi.org/10.1111/j.1474-8673.1988.tb00163.x
Abstract
1 6-hydroxydopamine (6-OHDA) reduced the noradrenaline content by 50% in the proximal branches of the canine mesenteric artery without significant change of dopamine content. For the main trunk from the same blood vessel a parallel depletion of dopamine and noradrenaline was found to occur. 2 In the proximal branches of control animals 43% of nerve profiles have a very high proportion of small dense cored vesicles (SDCV), whereas in the remaining nerve profiles the proportion of SDCV and large dense cored vesicles (LDCV) was about the same. In the main trunk 89% of nerve profiles have a similar proportion of both types of vesicles. 3 In the proximal branches, 6-OHDA drastically reduced the number of nerve profiles with a high proportion of SDCV, thus resulting in a preferential disappearance of SDCV. In the main trunk, 6-OHDA produced a parallel reduction of both SDCV and LDCV. 4 The results presented suggest that the 6-OHDA-insensitive dopamine pool found in the proximal branches of the mesenteric artery is mainly localized in LDCV, whereas SDCV appear to be the major store of noradrenaline.Keywords
This publication has 21 references indexed in Scilit:
- Vesicular Storage of 3,4‐Dihydroxyphenylethylamine and Noradrenaline in Terminal Sympathetic Nerves of Dog Spleen and KidneyJournal of Neurochemistry, 1986
- A STUDY OF THE RELATIONSHIP BETWEEN DOPAMINE AND NORADRENALINE CONTENT AND TRANSMURAL PRESSURE IN THE MESENTERIC ARTERIES OF THE DOGJournal of Autonomic Pharmacology, 1986
- The effects of chemical sympathectomy on dopamine, noradrenaline and adrenaline content in some peripheral tissuesBritish Journal of Pharmacology, 1985
- Morphological studies of stimulated adrenergic axon varicosities in the mouse vas deferens.The Journal of cell biology, 1979
- Evidence that most of the dopamine β-hydroxylase is not membrane bound in purified large dense cored noradrenergic vesiclesNeuroscience, 1978
- Biochemical observations on the formation of small noradrenergic vesicles in the splenic nerve of the dogNeuroscience, 1977
- Evidence for the presence of dopamine‐β‐hydroxylase in both populations of noradrenaline storage vesicles in sympathetic nerve terminals of the rat vas deferensJournal of Neurochemistry, 1973
- Synaptic vesicles in sympathetic neurons.Physiological Reviews, 1971
- An ultrastructural and histochemical study of the short‐term effects of 6‐hydroxydopamine on adrenergic nerves in the domestic fowlBritish Journal of Pharmacology, 1970
- Distribution of granular vesicles in normal and constricted sympathetic neuronesThe Journal of Physiology, 1969