Haemodynamic and Hormone Responses to Acute and Chronic Frusemide Therapy in Congestive Heart Failure
- 1 December 1980
- journal article
- research article
- Published by Portland Press Ltd. in Clinical Science
- Vol. 59 (6), 443-449
- https://doi.org/10.1042/cs0590443
Abstract
1. Since important interrelationships between haemodynamic and hormone indices are possible in cardiac failure, measurements of cardiac output, mean pulmonary artery pressure, plasma renin activity, angiotensin II and aldosterone were carried out before and during acute and chronic frusemide therapy in patients with oedematous heart failure who had been given digoxin. 2. Cardiac output fell significantly 90 min after acute frusemide injection, then returned to baseline. Mean pulmonary artery pressure declined steadily throughout the 4 h of observation. 3. These haemodynamic changes occurred in the absence of major hormonal fluctuations and related presumably to direct vascular and diuretic actions of frusemide. 4. With more chronic (8–10 days) oral frusemide therapy, reciprocal changes between haemodynamic and hormone indices were observed. As the diuretic response to frusemide diminished, cardiac output and pulmonary artery pressure declined whereas the renin-angiotensin system was activated. Statistically significant inverse correlations were observed between these haemodynamic and hormone indices. 5. In both acute and chronic phases of the study, fluctuations in aldosterone levels were regulated by the renin-angiotensin system whereas ACTH, plasma potassium and plasma sodium played, at best, supportive roles.Keywords
This publication has 12 references indexed in Scilit:
- Effects of the oral converting enzyme inhibitor SQ 14225 in experimental high output failureAmerican Journal of Physiology-Renal Physiology, 1979
- Angiotensin converting enzyme inhibition in patients with congestive heart failure.Cell Metabolism, 1978
- Role of the renin-angiotensin system in the systemic vasoconstriction of chronic congestive heart failure.Cell Metabolism, 1978
- Renin response to stimulation of cardiopulmonary mechanoreceptors in man.JCI Insight, 1978
- Renal function and renin secretion after administration of ouabain and ouabain plus furosemide in conscious sheep.Circulation Research, 1978
- The renin-angiotensin-aldosterone system in rabbits with congestive heart failure produced by aortic constriction.Circulation Research, 1977
- Furosemide inhibition of chloride transport in human red blood cells.The Journal of general physiology, 1976
- The renin-angiotensin-aldosterone system in congestive failure in conscious dogs.JCI Insight, 1976
- Outpatient Screening Tests for Primary AldosteronismAustralian and New Zealand Journal of Medicine, 1976
- Acute changes in plasma volume, renin activity, and free aldosterone levels in healthy subjects following Fursemide administrationCanadian Journal of Physiology and Pharmacology, 1968