Cement particles inhibit bone growth into titanium chambers implanted in the rabbit
Open Access
- 1 January 1993
- journal article
- research article
- Published by Medical Journals Sweden AB in Acta Orthopaedica
- Vol. 64 (6), 627-633
- https://doi.org/10.3109/17453679308994585
Abstract
Particles of bone cement have been shown previously to stimulate the resorption of bone. The purpose of this study was to determine whether particles of bone cement (BC) have an adverse effect on bone ingrowth. The bone harvest chamber was implanted bilaterally in the proximal tibial metaphysis of 6 mature rabbits. Both the fixed outer cylinder and the inner removable core of the chamber have a transverse 1 mm wide pore providing a continuous canal for tissue ingrowth. After an initial 6-week period for osseointegration of the outer cylinder, the contents of the inner core were harvested repeatedly at 3 weekly intervals. In the first series of rabbits, the carrier solution, 1 % sodium hyaluronate (Healon) was implanted first. In subsequent implantations, Healon was mixed with small fabricated particles of BC (averaging 3.54 mm in diameter) to fill the channel of the core. The contralateral chamber was left empty and served as a control. In the second series of rabbits, implantation was carried out sequentially using the same material bilaterally. The sections from the control harvests, and those with Healon alone contained extensive trabecular bone arranged longitudinally in the canal, in a fibrovascular stroma. The sections containing BC particles were infiltrated by foamy, mononuclear and multinuclear histiocytic cells. Less trabecular bone was seen in the sections containing BC particles compared to the control sections or those containing Healon alone. Previous studies have shown that particles of bone cement stimulate bone resorption. In this study, BC particles have also been shown to diminish the formation of new bone.Keywords
This publication has 25 references indexed in Scilit:
- Prostaglandin E2 Levels in the Membrane Surrounding Bulk and Particulate Polymethylmethacrylate in the Rabbit TibiaPublished by Ovid Technologies (Wolters Kluwer Health) ,1990
- Biomechanical and Histologic Investigation of Cemented Total Hip ArthroplastiesClinical Orthopaedics and Related Research, 1989
- A Clinical-Pathologic-Biochemical Study of the Membrane Surrounding Loosened and Nonloosened Total Hip ArthroplastiesClinical Orthopaedics and Related Research, 1989
- Recurrent bone regeneration in titanium implants. Experimental model for determining the healing capacity of bone using quantitative microradiographyBiomaterials, 1988
- The Effects of Bulk Versus Particulate Polymethylmethacrylate on BoneClinical Orthopaedics and Related Research, 1988
- Cement DiseasePublished by Ovid Technologies (Wolters Kluwer Health) ,1987
- The Microscopic Anatomy of the Bone-Cement Interface in Failed Total Hip ArthroplastiesPublished by Ovid Technologies (Wolters Kluwer Health) ,1987
- Morphological Changes in Bone Following Intramedullary Implantation of Methyl Methacrylate: Effects of Medullary Occlusion: A Morphometrical StudyActa Orthopaedica, 1983
- The Pathology of Failed Total Joint ArthroplastyPublished by Ovid Technologies (Wolters Kluwer Health) ,1982
- The Influence of Acrylic Cement: An Experimental StudyActa Orthopaedica, 1971