The Krüppel-like zinc finger protein GLIS3 transactivates neurogenin 3 for proper fetal pancreatic islet differentiation in mice
Open Access
- 23 July 2011
- journal article
- research article
- Published by Springer Science and Business Media LLC in Diabetologia
- Vol. 54 (10), 2595-2605
- https://doi.org/10.1007/s00125-011-2255-9
Abstract
Mutations in GLIS3, which encodes a Krüppel-like zinc finger transcription factor, were found to underlie sporadic neonatal diabetes. Inactivation of Glis3 by gene targeting in mice was previously shown to lead to neonatal diabetes, but the underlying mechanism remains largely unknown. We aimed to elucidate the mechanism of action of GLIS family zinc finger 3 (GLIS3) in Glis3 −/− mice and to further decipher its action in in-vitro systems.Keywords
This publication has 43 references indexed in Scilit:
- Neonatal diabetes mellitus: A model for personalized medicineTrends in Endocrinology & Metabolism, 2010
- Transcription Factor Glis3, a Novel Critical Player in the Regulation of Pancreatic β-Cell Development and Insulin Gene ExpressionMolecular and Cellular Biology, 2009
- The diabetes gene Pdx1 regulates the transcriptional network of pancreatic endocrine progenitor cells in miceJCI Insight, 2009
- The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcriptionNucleic Acids Research, 2009
- Neurogenin3 Is Sufficient for Transdetermination of Hepatic Progenitor Cells into Neo-Islets In Vivo but Not Transdifferentiation of HepatocytesDevelopmental Cell, 2009
- On the origin of the β cellGenes & Development, 2008
- The transcription factors Nkx6.1 and Nkx6.2 possess equivalent activities in promoting beta-cell fate specification in Pdx1+ pancreatic progenitor cellsDevelopment, 2007
- Sox9 coordinates a transcriptional network in pancreatic progenitor cellsProceedings of the National Academy of Sciences of the United States of America, 2007
- Analysis of pancreatic endocrine development in GDF11‐deficient miceDevelopmental Dynamics, 2006
- Derivation of completely cell culture-derived mice from early-passage embryonic stem cells.Proceedings of the National Academy of Sciences of the United States of America, 1993