Successful Treatment of Chronic Recurrent Multifocal Osteomyelitis With Tumor Necrosis Factor-α Blockage
- 1 November 2005
- journal article
- case report
- Published by American Academy of Pediatrics (AAP)
- Vol. 116 (5), 1231-1233
- https://doi.org/10.1542/peds.2004-2206
Abstract
We describe the case of an 18-year-old girl with chronic recurrent multifocal osteomyelitis (CRMO) over a period of 10 years. She had suffered predominantly from very painful recurrent swelling of her cheeks. Various therapeutic regimens including nonsteroidal antiinflammatory drugs and steroids had shown only a partial or temporary response. Because tumor necrosis factor-α–blocking agents have been successfully applied in Crohn's-associated CRMO and the related SAPHO (synovitis, acne, pustulosis, hyperostosis, and osteitis) syndrome, tumor necrosis factor-α–blocking therapy with infliximab was initiated. Thereafter, apart from 1 mild episode, no additional recurrences were observed during 21 months of follow-up. Infliximab was well tolerated, and steroids were tapered off. Our observation indicates that infliximab may be an effective therapeutic option in CRMO.Keywords
This publication has 9 references indexed in Scilit:
- Crohn's-associated chronic recurrent multifocal osteomyelitis responsive to infliximabThe Journal of Pediatrics, 2004
- Sustained response to tumor necrosis factor α–blocking agents in two patients with SAPHO syndromeArthritis & Rheumatism, 2002
- Successful treatment of SAPHO syndrome with infliximab: report of two casesAnnals Of The Rheumatic Diseases, 2002
- Chronic recurrent multifocal osteomyelitis (CRMO): evidence for a susceptibility gene located on chromosome 18q21.3-18q22European Journal of Human Genetics, 2002
- Die Chronische rekurrierende multifokale Osteomyelitis (CRMO)* - Teil 1 Übersicht -Klinische Padiatrie, 2001
- Fatal Sepsis in a Patient With Rheumatoid Arthritis Treated With EtanerceptMayo Clinic Proceedings, 2001
- SAPHO: Rare or just not recognized?Seminars in Arthritis and Rheumatism, 2000
- Chronic recurrent multifocal osteomyelitis in children: Diagnostic value of histopathology and microbial testingHuman Pathology, 1999
- The Tumor Necrosis Factor Ligand and Receptor FamiliesNew England Journal of Medicine, 1996