Raisins and additional walking have distinct effects on plasma lipids and inflammatory cytokines
Open Access
- 16 April 2008
- journal article
- research article
- Published by Springer Science and Business Media LLC in Lipids in Health and Disease
- Vol. 7 (1), 14
- https://doi.org/10.1186/1476-511x-7-14
Abstract
Background Raisins are a significant source of dietary fiber and polyphenols, which may reduce cardiovascular disease (CVD) risk by affecting lipoprotein metabolism and inflammation. Walking represents a low intensity exercise intervention that may also reduce CVD risk. The purpose of this study was to determine the effects of consuming raisins, increasing steps walked, or a combination of these interventions on blood pressure, plasma lipids, glucose, insulin and inflammatory cytokines. Results Thirty-four men and postmenopausal women were matched for weight and gender and randomly assigned to consume 1 cup raisins/d (RAISIN), increase the amount of steps walked/d (WALK) or a combination of both interventions (RAISINS + WALK). The subjects completed a 2 wk run-in period, followed by a 6 wk intervention. Systolic blood pressure was reduced for all subjects (P = 0.008). Plasma total cholesterol was decreased by 9.4% for all subjects (P < 0.005), which was explained by a 13.7% reduction in plasma LDL cholesterol (LDL-C) (P < 0.001). Plasma triglycerides (TG) concentrations were decreased by 19.5% for WALK (P < 0.05 for group effect). Plasma TNF-α was decreased from 3.5 ng/L to 2.1 ng/L for RAISIN (P < 0.025 for time and group × time effect). All subjects had a reduction in plasma sICAM-1 (P < 0.01). Conclusion This research shows that simple lifestyle modifications such as adding raisins to the diet or increasing steps walked have distinct beneficial effects on CVD risk.Keywords
This publication has 54 references indexed in Scilit:
- The effect of red wine on plasma leptin levels and vasoactive factors from adipose tissue: A randomized crossover trialAlcohol and Alcoholism, 2007
- Exercise and diet induced weight loss improves measures of oxidative stress and insulin sensitivity in adults with characteristics of the metabolic syndromeAmerican Journal of Physiology-Endocrinology and Metabolism, 2007
- A physical activity programme and its effects on insulin resistance and oxidative defense in obese male patients with type 2 diabetes mellitusDiabetes & Metabolism, 2006
- The metabolic syndrome and cardiovascular diseaseAnnals of Medicine, 2006
- Physical activity and modulation of systemic low-level inflammationJournal of Leukocyte Biology, 2005
- Different effects of red wine and gin consumption on inflammatory biomarkers of atherosclerosis: a prospective randomized crossover trial: Effects of wine on inflammatory markersAtherosclerosis, 2004
- Hepatocyte ApoB-Containing Lipoprotein Secretion Is Decreased by the Grapefruit Flavonoid, Naringenin, via Inhibition of MTP-Mediated Microsomal Triglyceride AccumulationBiochemistry, 2003
- Exercise and Insulin Sensitivity: A ReviewInternational Journal of Sports Medicine, 2000
- Interleukin-10Annual Review of Immunology, 1993
- Tumor necrosis factor Characterization at the molecular, cellular and in vivo levelFEBS Letters, 1991