Autoimmunity in spontaneous myasthenia gravis in dogs
- 31 December 1984
- journal article
- research article
- Published by Elsevier BV in Clinical Immunology and Immunopathology
- Vol. 31 (2), 301-306
- https://doi.org/10.1016/0090-1229(84)90250-2
Abstract
Spontaneous canine myasthenia gravis (MG) mimics the human disease in almost every respect. Both dogs reported here exhibited the autoantibodies characteristic of MG, i.e., anti-acetylcholine receptor (anti-AChR) and antistriational (AStr). Fluctuations in the anti-AChR titer during spontaneous remission and recurrence of MG in one dog provide support for the concept of a symptomatic threshold titer above which anti-AChR must rise before disease signs develop. The increase in the anti-AChR titer and recurrence of disease signs followed vaccination and an infection. Interestingly AStr also reappeared in this dog and serum IgG concentration increased. AStr in the second dog was associated with the presence of a thymoma and had a staining pattern characteristic of human MG.Keywords
This publication has 11 references indexed in Scilit:
- The diagnostic significance of autoantibodies to the acetylcholine receptorJournal of Neuroimmunology, 1982
- INTRODUCTION MYASTHENIA GRAVIS-RETROSPECT AND PROSPECTAnnals of the New York Academy of Sciences, 1981
- Role of polyclonal B-cell activation in self/non-self discriminationImmunology Today, 1981
- The Biology of Myasthenia GravisAnnual Review of Neuroscience, 1981
- No direct correlation between serum antiacetylcholine receptor antibody levels and clinical state of individual patients with myasthenia gravisNeurology, 1981
- Detection of thymoma in myasthenia gravisNeurology, 1980
- Genetic control of suppressor lymphocyte function in myasthenia gravis: Relationship of impaired suppressor function to HLA-B8DRW3 and cold reactive lymphocytotoxic antibodiesClinical Immunology and Immunopathology, 1979
- Function of circulating antibody to acetylcholine receptor in myasthenia gravisNeurology, 1978
- An assay for antibodies to human acetylcholine receptor in serum from patients with myasthenia gravisClinical Immunology and Immunopathology, 1977
- Autoimmune Response to Acetylcholine ReceptorScience, 1973