Synthesis and X-ray structure analysis of a heptacoordinate titanium(iv)-bis-chelate with enhanced in vivo antitumor efficacy
- 17 April 2012
- journal article
- research article
- Published by Royal Society of Chemistry (RSC) in Chemical Communications
- Vol. 48 (46), 5790-5792
- https://doi.org/10.1039/c2cc31624b
Abstract
Chelate stabilization of a titanium(IV)–salan alkoxide by ligand exchange with 2,6-pyridinedicarboxylic acid (dipic) resulted in heptacoordinate complex 3 which is not redox-active, stable on silica gel and has increased aqueous stability. 3 is highly toxic in HeLa S3 and Hep G2 and has enhanced antitumor efficacy in a mouse cervical-cancer model.Keywords
This publication has 34 references indexed in Scilit:
- Bioinorganic Chemistry of TitaniumChemical Reviews, 2011
- Titanocene Difluorides with Improved Cytotoxic ActivityInorganic Chemistry, 2010
- Modern cytotoxic titanium(IV) complexes; Insights on the enigmatic involvement of hydrolysisCoordination Chemistry Reviews, 2009
- Cytotoxic Titanium(IV) Complexes: RenaissanceEuropean Journal of Inorganic Chemistry, 2009
- Bioorganometallic fulvene-derived titanocene anti-cancer drugsChemical Society Reviews, 2008
- Active Cytotoxic Reagents Based on Non-metallocene Non-diketonato Well-Defined C2-Symmetrical Titanium Complexes of Tetradentate Bis(phenolato) LigandsJournal of the American Chemical Society, 2007
- Antitumour bis(cyclopentadienyl) metal complexes: titanocene and molybdocene dichloride and derivativesDalton Transactions, 2007
- Titanium complexes in cancer treatmentCritical Reviews in Oncology/Hematology, 2002
- Salan complexes of the group 12, 13 and 14 elementsCoordination Chemistry Reviews, 1997
- Tumor-inhibiting bis(β-Diketonato) metal complexes. Budotitane, cis-diethoxybis(1-phenylbutane-1,3-dionato)titanium(IV)Published by Springer Science and Business Media LLC ,1991