Neurotensin induced inhibition of gastric acid secretion in duodenal ulcer patients before and after parietal cell vagotomy.
Open Access
- 1 May 1984
- Vol. 25 (5), 481-484
- https://doi.org/10.1136/gut.25.5.481
Abstract
The influence of the vagal nerve on the inhibitory effect of neurotensin on pentagastrin stimulated gastric acid secretion was investigated in seven duodenal ulcer patients before and after parietal cell vagotomy without drainage. Preoperatively, neurotensin inhibited gastric acid secretion, whereas no effect was found postoperatively. Plasma concentration of neurotensin was identical pre-and postoperatively. This study shows that the inhibitory effect of neurotensin on gastric acid secretion is dependent on an intact vagal innervation of the parietal cell area.Keywords
This publication has 15 references indexed in Scilit:
- Neurotensin Inhibits Meal-Stimulated Gastric Acid Secretion in ManScandinavian Journal of Gastroenterology, 1983
- Preparation of125I-(Tyr 3)- and125I-(Tyr 11)-neurotensin for radioimmunoassayScandinavian Journal of Clinical and Laboratory Investigation, 1983
- Vagal Control of Glucagon-Induced Inhibition of Gastric Acid Secretion in Duodenal Ulcer PatientsScandinavian Journal of Gastroenterology, 1982
- Fat Inhibition of Gastric Acid Secretion in Man and Plasma Concentrations of Neurotensin-Like ImmunoreactivityScandinavian Journal of Gastroenterology, 1981
- Prospective Controlled Vagotomy Trial for Duodenal UlcerAnnals of Surgery, 1981
- Fat inhibition of gastric acid secretion in duodenal ulcer patients before and after proximal gastric vagotomy.Gut, 1980
- EFFECT OF NEUROTENSIN ON GASTRIC FUNCTION IN MANThe Lancet, 1980
- Specific localisation of neurotensin to the N cell in human intestine by radioimmunoassay and immunocytochemistryNature, 1977
- Inhibition of gastric acid secretion in dogs by neurotensinLife Sciences, 1976
- Effect of Glucagon on Gastric Secretion in ManGut, 1960