Reduction of Endogenous Angiogenesis Inhibitors in Bruch's Membrane of the Submacular Region in Eyes With Age-Related Macular Degeneration

Abstract

Choroidal neovascularization (CNV) is a major cause of vision loss in patients with age-related macular degeneration (AMD).¹ Because the exact mechanism underlying the pathogenesis of CNV is still poorly understood, identifying risk factors and preventive strategies is important to decrease the effect and burden of blindness from this condition. Several theories of pathogenesis have been proposed, including retinal pigment epithelium (RPE) dysfunction, alterations in Bruch's membrane, oxidative stress, genetic defects, ocular perfusion abnormalities, inflammatory processes, and ischemia.^2,3