Maintenance of stem cell populations in plants
- 30 September 2003
- journal article
- review article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences
- Vol. 100 (suppl_1), 11823-11829
- https://doi.org/10.1073/pnas.1834206100
Abstract
Flowering plants have the unique ability to produce new organs continuously, for hundreds of years in some species, from stem cell populations maintained at their actively growing tips. The shoot tip is called the shoot apical meristem, and it acts as a self-renewing source of undifferentiated, pluripotent stem cells whose descendents become incorporated into organ and tissue primordia and acquire different fates. Stem cell maintenance is an active process, requiring constant communication between different regions of the shoot apical meristem to coordinate loss of stem cells from the meristem through differentiation with their replacement through cell division. Stem cell research in model plant systems is facilitated by the fact that mutants with altered meristem cell identity or accumulation are viable, allowing dissection of stem cell behavior by using genetic, molecular, and biochemical methods. Such studies have determined that in the model plant Arabidopsis thaliana stem cell maintenance information flows via a signal transduction pathway that is established during embryogenesis and maintained throughout the life cycle. Signaling through this pathway results in the generation of a spatial feedback loop, involving both positive and negative interactions, that maintains stem cell homeostasis. Stem cell activity during reproductive development is terminated by a temporal feedback loop involving both stem cell maintenance genes and a phase-specific flower patterning gene. Our current investigations provide additional insights into the molecular mechanisms that regulate stem cell activity in higher plants.Keywords
This publication has 62 references indexed in Scilit:
- VH1, a Provascular Cell–Specific Receptor Kinase That Influences Leaf Cell Patterns in ArabidopsisPlant Cell, 2002
- CLV3 Is Localized to the Extracellular Space, Where It Activates the Arabidopsis CLAVATA Stem Cell Signaling PathwayPlant Cell, 2002
- MAP kinase signalling cascade in Arabidopsis innate immunityNature, 2002
- Receptor-like kinases from Arabidopsis form a monophyletic gene family related to animal receptor kinasesProceedings of the National Academy of Sciences of the United States of America, 2001
- The Rop GTPase Switch Controls Multiple Developmental Processes in ArabidopsisPlant Physiology, 2001
- Genetic Control of Cell Division Patterns in Developing PlantsCell, 1997
- Localization of a Rho GTPase Implies a Role in Tip Growth and Movement of the Generative Cell in Pollen Tubes.Plant Cell, 1996
- A gene triggering flower formation in ArabidopsisNature, 1995
- The war of the whorls: genetic interactions controlling flower developmentNature, 1991
- Cell lineage patterns in maize embryogenesis: A clonal analysisDevelopmental Biology, 1986