Cryobiology: The Freezing of Biological Systems
- 22 May 1970
- journal article
- research article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 168 (3934), 939-949
- https://doi.org/10.1126/science.168.3934.939
Abstract
Treatment of cultured rat pineal glands with norepinephrine or dibutyryl adenosine 3',5'-monophosphate causes a six- to tenfold stimulation of N-acetyltransferase. This enzyme converts serotonin to N-acetylserotonin, the immediate precursor of melatonin. The increased synthesis of melatonin caused by norepinephrine treatment appears to be the result of stimulation of N-acetyltransferase by an adenosine 3',5'-monophosphate mechanism.Keywords
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