Antiplasmodial Marine Natural Products in the Perspective of Current Chemotherapy and Prevention of Malaria. A Review
- 30 March 2006
- journal article
- review article
- Published by Springer Science and Business Media LLC in Marine Biotechnology
- Vol. 8 (5), 433-447
- https://doi.org/10.1007/s10126-006-6100-y
Abstract
The difficulty of obtaining an antimalarial vaccine along traditional lines, because of the highly adaptive character of the malaria parasite, prompts a ceaseless need for new drugs. To this end, marine organisms have been explored recently, as reviewed in this article within the perspective of clinically available antimalarial drugs and promising candidates. Most promising are tetrahydropyrrolo[1,2-α]pyrimidinium, bis-indole, and C11–N5 alkaloids from sponges; pyridoacridone and decahydroquinoline alkaloids from ascidians; and pyrrole alkaloids from fungi, as well as polycyclic polyketides, norditerpene, and polyketide endoperoxides, terpene isonitriles, and, particularly, mixed-biogenesis α-galactosyl ceramides from sponges. The first and the latter classes of agents best fulfill the requirements for combinatorial synthesis in providing a wide variety of compounds for high-throughput screening and toxicity tests. These results came largely from nonprofit organizations, a trend that we foresee will continue. However, partnership with the pharmaceutical industry was and is needed to bring candidate drugs to the clinic. In any event, success will not be achieved without political plans to make the results of technology easily available to poor populations.Keywords
This publication has 98 references indexed in Scilit:
- Resistance of Plasmodium falciparum field isolates to in-vitro artemether and point mutations of the SERCA-type PfATPase6The Lancet, 2005
- PfPK7, an atypical MEK‐related protein kinase, reflects the absence of classical three‐component MAPK pathways in the human malaria parasite Plasmodium falciparumMolecular Microbiology, 2004
- Identification and Initial Characterization of Three Novel Cyclin-related Proteins of the Human Malaria Parasite Plasmodium falciparumPublished by Elsevier BV ,2003
- Roscovitine and Other Purines as Kinase Inhibitors. From Starfish Oocytes to Clinical TrialsAccounts of Chemical Research, 2003
- Genome sequence of the human malaria parasite Plasmodium falciparumNature, 2002
- New Types of Potentially Antimalarial Agents: Epidioxy‐substituted norditerpene and norsesterpenes from the marine sponge Diacarnus leviiHelvetica Chimica Acta, 1998
- Novel Potent Antimalarial Diterpene Isocyanates, Isothiocyanates, and Isonitriles from the Tropical Marine Sponge Cymbastela hooperiThe Journal of Organic Chemistry, 1996
- Antifungal Peroxyketal Acids from an Okinawan Marine Sponge of Plakortis sp.CHEMICAL & PHARMACEUTICAL BULLETIN, 1993
- Monoterpenic fragment analogs of aplasmomycin as potential antimalarialsJournal of Medicinal Chemistry, 1991
- Marine natural products. XII. On the chemical constituents of the Okinawan marine sponge Hymeniacidon aldis.CHEMICAL & PHARMACEUTICAL BULLETIN, 1983