Impulse-control disorders in Parkinson's disease.
- 1 August 2008
- journal article
- review article
- Published by Cambridge University Press (CUP) in CNS Spectrums
- Vol. 13 (8), 690-698
- https://doi.org/10.1017/s1092852900013778
Abstract
Parkinson's disease is a neurodegenerative disorder characterized by bradykinesia, rigidity, postural instability, and resting tremor. Increasingly, Parkinson's disease has been associated with a broad spectrum of non-motor symptoms, such as olfactory loss, sleep disorders, autonomic dysfunction, cognitive impairment, psychosis, depression, anxiety, and apathy. In addition, a minority of Parkinson's disease patients develop compulsive behaviors while receiving dopamine-replacement therapy, including medication hoarding, pathological gambling, binge eating, hyperlibidinous behavior, compulsive shopping, and punding. These behaviors may result in psychosocial impairment for patients and therapeutic challenges for clinicians. This article reviews the anatomic substrates, behavioral spectrum, associated factors, and potential treatments for dopamine-replacement therapy-related compulsions in Parkinson's disease.Keywords
This publication has 71 references indexed in Scilit:
- Long‐term follow‐up of impulse control disorders in Parkinson's diseaseMovement Disorders, 2008
- Pathological gambling after bilateral subthalamic nucleus stimulation in Parkinson diseaseJournal of Neurology, Neurosurgery & Psychiatry, 2006
- Punding and dyskinesiasMovement Disorders, 2006
- Association of Dopamine Agonist Use With Impulse Control Disorders in Parkinson DiseaseArchives of Neurology, 2006
- Effects of Donepezil on Compulsive Hypersexual Behavior in Parkinson DiseaseClinical Journal of Sport Medicine, 2005
- Punding in Parkinson′s disease related to high-dose levodopa therapyNeurology India, 2005
- Hedonistic homeostatic dysregulation in Parkinson’s disease: a short screening questionnaireNeurological Sciences, 2003
- Transient mania with hypersexuality after surgery for high frequency stimulation of the subthalamic nucleus in Parkinson's diseaseMovement Disorders, 2002
- Behavioural disorders, Parkinson's disease and subthalamic stimulationJournal of Neurology, Neurosurgery & Psychiatry, 2002
- THE BASAL GANGLIA: FOCUSED SELECTION AND INHIBITION OF COMPETING MOTOR PROGRAMSProgress in Neurobiology, 1996