Flavanones with Potent Antibacterial Activity against Methicillin-resistant Staphylococcus aureus
- 1 November 1994
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 46 (11), 892-895
- https://doi.org/10.1111/j.2042-7158.1994.tb05709.x
Abstract
With the therapeutic concept of using the defensive ability of plants against microbial infections, phytoalexin, an antimicrobial phytochemical was studied for its ability to inhibit the growth of methicillin-resistant Staphylococcus aureus (MRSA). Extracts from Sophora exigua (Leguminosae) were fractionated by serial chromatography and the anti-MRSA activity of each fraction was determined by the agar-plate method. Among the active isolates, 5,7,2′,6′-tetrahydroxy-6-isoprenyl-8-lavandulyl-4′-methoxyflavanone (exiguaflavanone D) completely inhibited the growth of all the MRSA strains examined at the concentration of 1·56–6·25 μg mL−1, and 5, 2′,6′-trihydroxy-8-lavandulyl-7-methoxy-flavanone (exiguaflavanone B) inhibited at a concentration of 50 μg mL−1. This former compound is expected to be a phytotherapeutic agent for MRSA infections as an alternative to conventional antibiotics with unwanted side-effects or the appearance of antibiotic-resistant bacteria.Keywords
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