Late reversal reaction with resistantMycobacterium leprae: an emerging paradigm
- 9 November 2019
- journal article
- research article
- Published by SAGE Publications in Tropical Doctor
- Vol. 50 (1), 77-81
- https://doi.org/10.1177/0049475519884421
Abstract
While Type 1 reaction is seen in leprosy patients, in up to 30% of patients, late reaction is uncommon and usually is seen in the first two years of release from treatment (RFT). It is believed that these reactions are consequent to dead bacilli and the World Health Organization recommends treatment with steroids without multidrug therapy (MDT; with the proviso of adding clofazimine only when steroid therapy exceeds four months duration). A few studies, though, have noted live bacilli present in reversal reactions and hence recommend concomitant MDT. We report a case of resistant bacilli in late reaction and discuss the implications of this finding.Keywords
This publication has 5 references indexed in Scilit:
- Association of viable Mycobacterium leprae with Type 1 reaction in leprosyLeprosy Review, 2016
- Leprosy type 1 reaction (formerly reversal reaction)Clinics in Dermatology, 2016
- The effect of corticosteroids usage on bacterial killing, clearance and nerve damage in leprosy; Part 3 – Study of two comparable groups of 100 multibacillary (MB) patients each, treated with MDT + steroids vs MDT alone, assessed at 6 months post – release from 12 months MDTLeprosy Review, 2010
- Quantitative real-time PCR analysis of Mycobacterium leprae DNA and mRNA in human biopsy material from leprosy and reactional casesJournal of Medical Microbiology, 2009
- Relapses vs. reactions in multibacillary leprosy: proposal of new relapse criteriaTropical Medicine & International Health, 2008