Synthesis and biological activities of meribendan and related heterocyclic benzimidazolo-pyridazinones
- 31 December 1993
- journal article
- Published by Elsevier BV in European Journal of Medicinal Chemistry
- Vol. 28 (2), 129-140
- https://doi.org/10.1016/0223-5234(93)90005-y
Abstract
The synthesis of new heterocyclic benzimidazolo-pyridazinones is described. The new compounds were evaluated as inotropic agents with ‘calcium-sensitizing’ effects. 5-Methyl-6-[2-(3-pyrazolyl)-5-benzimidazolyl]-2,3,4,5-tetrahydro-pyridazin-3-one hydrochloride (meribendan) turned out to be the most interesting compound and was chosen for development as a positive inotrope.Keywords
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