Indoor Residual Spraying of Insecticide and Malaria Morbidity in a High Transmission Intensity Area of Uganda
Open Access
- 6 August 2012
- journal article
- research article
- Published by Public Library of Science (PLoS) in PLOS ONE
- Vol. 7 (8), e42857
- https://doi.org/10.1371/journal.pone.0042857
Abstract
Recently the use of indoor residual spraying of insecticide (IRS) has greatly increased in Africa; however, limited data exist on the quantitative impacts of IRS on health outcomes in highly malaria endemic areas. Routine data were collected on more than 90,000 patient visits at a single health facility over a 56 month period covering five rounds of IRS using three different insecticides. Temporal associations between the timing of IRS and the probability of a patient referred for microscopy having laboratory confirmed malaria were estimated controlling for seasonality and age. Considering patients less than five years of age there was a modest decrease in the odds of malaria following the 1st round of IRS using DDT (OR = 0.76, pnd round using alpha-cypermethrin (OR = 0.83, p = 0.002). Following rounds 3–5 using bendiocarb there was a much greater decrease in the odds of malaria (ORs 0.34, 0.16, 0.17 respectively, p<0.001 for all comparisons). Overall, the impact of IRS was less pronounced among patients 5 years or older. IRS was associated with a reduction in malaria morbidity in an area of high transmission intensity in Uganda and the benefits appeared to be greatest after switching to a carbamate class of insecticide.Keywords
This publication has 24 references indexed in Scilit:
- Malaria in Uganda: Challenges to control on the long road to elimination: I. Epidemiology and current control effortsActa Tropica, 2012
- The Combination of Indoor Residual Spraying and Insecticide-Treated Nets Provides Added Protection against Malaria Compared with Insecticide-Treated Nets AloneThe American Journal of Tropical Medicine and Hygiene, 2011
- Dramatic Decrease in Malaria Transmission after Large-Scale Indoor Residual Spraying with Bendiocarb in Benin, an Area of High Resistance of Anopheles gambiae to PyrethroidsThe American Journal of Tropical Medicine and Hygiene, 2011
- Insecticide resistance in malaria vector mosquitoes at four localities in Ghana, West AfricaParasites & Vectors, 2011
- The emergence of insecticide resistance in central Mozambique and potential threat to the successful indoor residual spraying malaria control programmeMalaria Journal, 2011
- Improved Malaria Case Management through the Implementation of a Health Facility-Based Sentinel Site Surveillance System in UgandaPLOS ONE, 2011
- Pyrethroid Resistance in an Anopheles funestus Population from UgandaPLOS ONE, 2010
- Spatio-Temporal Patterns in kdr Frequency in Permethrin and DDT Resistant Anopheles gambiae s.s. from UgandaThe American Journal of Tropical Medicine and Hygiene, 2010
- Insecticide resistance status in Anopheles gambiae in southern BeninMalaria Journal, 2010
- Use of the slide positivity rate to estimate changes in malaria incidence in a cohort of Ugandan childrenMalaria Journal, 2009