Circular RNAs in cell differentiation and development
- 15 August 2020
- journal article
- review article
- Published by The Company of Biologists in Development
- Vol. 147 (16)
- https://doi.org/10.1242/dev.182725
Abstract
In recent years, circular RNAs (circRNAs) – a novel class of RNA molecules characterized by their covalently closed circular structure – have emerged as a complex family of eukaryotic transcripts with important biological features. Besides their peculiar structure, which makes them particularly stable molecules, they have attracted much interest because their expression is strongly tissue and cell specific. Moreover, many circRNAs are conserved across eukaryotes, localized in particular subcellular compartments, and can play disparate molecular functions. The discovery of circRNAs has therefore added not only another layer of gene expression regulation but also an additional degree of complexity to our understanding of the structure, function and evolution of eukaryotic genomes. In this Review, we summarize current knowledge of circRNAs and discuss the possible functions of circRNAs in cell differentiation and development.Keywords
Funding Information
- European Research Council (ERC-2019-SyG 855923-ASTRA)
- Fondazione Telethon (GGP16213)
- Associazione Italiana per la Ricerca sul Cancro (IG 2019 Id. 23053)
- Ministero dell'Istruzione, dell'Università e della Ricerca (PRIN 2017 2017P352Z4)
- H2020 Marie Skłodowska-Curie Actions (H2020-MSCA-ITN-2016)
This publication has 97 references indexed in Scilit:
- WNT signaling in neuronal maturation and synaptogenesisFrontiers in Cellular Neuroscience, 2013
- Circular RNAs are abundant, conserved, and associated with ALU repeatsRNA, 2012
- Circular RNAs Are the Predominant Transcript Isoform from Hundreds of Human Genes in Diverse Cell TypesPLOS ONE, 2012
- Building Muscle: Molecular Regulation of MyogenesisCold Spring Harbor Perspectives in Biology, 2012
- Wnt Signaling in the Vertebrate Central Nervous System: From Axon Guidance to Synaptic FunctionCold Spring Harbor Perspectives in Biology, 2012
- TGF-β Signaling Specifies Axons during Brain DevelopmentCell, 2010
- Systematic identification of abundant A-to-I editing sites in the human transcriptomeNature Biotechnology, 2004
- Periodic Explosive Expansion of Human Retroelements Associated with the Evolution of the Hominoid PrimateJournal of Korean Medical Science, 2004
- Circular transcripts of the testis-determining gene Sry in adult mouse testisCell, 1993
- Scrambled exonsCell, 1991