Mood disorders following traumatic brain injury
- 1 November 2003
- journal article
- review article
- Published by Informa UK Limited in International Review of Psychiatry
- Vol. 15 (4), 317-327
- https://doi.org/10.1080/09540260310001606700
Abstract
Mood disorders are a frequent complication of traumatic brain injury that exerts a deleterious effect on the recovery process and psychosocial outcome of brain injured patients. Prior psychiatric history and impaired social support have been consistently reported as risk factors for developing mood disorders after traumatic brain injury (TBI). In addition, biological factors such as the involvement of the prefrontal cortex and probably other limbic and paralimbic structures may play a significant role in the complex pathophysiology of these disorders. Preliminary studies have suggested that selective serotonin reuptake inhibitors such as sertraline, mood stabilizers such as sodium valproate, as well as stimulants and ECT may be useful in treating these disorders. Mood disorders occurring after TBI are clearly an area of neuropsychiatry in which further research in etiology as well as treatment is needed.Keywords
This publication has 42 references indexed in Scilit:
- The Clinical Significance of Major Depression Following Mild Traumatic Brain InjuryPsychosomatics, 2003
- Peer Support in the CommunityJournal of Head Trauma Rehabilitation, 2002
- The prevalence and symptom rates of depression after traumatic brain injury: a comprehensive examinationBrain Injury, 2001
- Antidepressant Pharmacotherapy and the Treatment of Depression in Patients With Severe Traumatic Brain InjuryThe Journal of Clinical Psychiatry, 1996
- Influence of major depression on 1-year outcome in patients with traumatic brain injuryJournal of Neurosurgery, 1994
- Alterations in Regional Brain Catecholamine Concentrations After Experimental Brain Injury in the RatJournal of Neurochemistry, 1994
- Mania following head injury: Case reports and neuropsychological findingsActa Psychiatrica Scandinavica, 1988
- Mania Following Head InjuryThe British Journal of Psychiatry, 1987
- Mania Following Head InjuryThe British Journal of Psychiatry, 1987
- Patient outcome in the year following severe head injury and relatives' psychiatric and social functioning.Journal of Neurology, Neurosurgery & Psychiatry, 1985