γ-Lactones and ent-Eudesmane Sesquiterpenes from the Endophytic Fungus Eutypella sp. BCC 13199
- 9 September 2009
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Natural Products
- Vol. 72 (9), 1720-1722
- https://doi.org/10.1021/np900316x
Abstract
Two new γ-lactones, eutypellins A (1) and B (2), and two ent-eudesmane sesquiterpenes, ent-4(15)-eudesmen-11-ol-1-one (3) and ent-4(15)-eudesmen-1α,11-diol (4), together with three known pimarane diterpenes, diaporthein B, scopararane A, and libertellenone C, were isolated from the endophytic fungus Eutypella sp. BCC 13199. The structures of these compounds were elucidated by interpretation of spectroscopic data. The absolute configuration of 4 was confirmed by application of the modified Mosher’s method. Eutypellin A (1) and sesquiterpene 3 exhibited weak cytotoxic activities.Keywords
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