Identification of a Graft Versus Host Disease-Associated Human Minor Histocompatibility Antigen
- 9 June 1995
- journal article
- other
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 268 (5216), 1476-1480
- https://doi.org/10.1126/science.7539551
Abstract
Minor histocompatibility antigen disparities between human leukocyte antigen (HLA)-matched bone marrow donors and recipients are a major risk factor for graft versus host disease (GVHD). An HLA-A2.1-restricted cytotoxic T cell clone that recognized the minor histocompatibility antigen HA-2 was previously isolated from a patient with severe GVHD after HLA-identical bone marrow transplantation. The HLA-A2.1-bound peptide representing HA-2 has now been identified. This peptide appears to originate from a member of the non-filament-forming class I myosin family. Because HA-2 has a phenotype frequency of 95 percent in the HLA-A2.1-positive population, it is a candidate for immunotherapeutic intervention in bone marrow transplantation.This publication has 35 references indexed in Scilit:
- Cloning and mRNA Expression of Human Unconventional Myosin-IC: A Homologue of Amoeboid Myosins-I With a Single IQ Motif and an SH3 DomainJournal of Molecular Biology, 1994
- Identification of a Peptide Recognized by Five Melanoma-Specific Human Cytotoxic T Cell LinesScience, 1994
- Prominent role of secondary anchor residues in peptide binding to HLA-A2.1 moleculesCell, 1993
- A multitude of myosinsCurrent Biology, 1993
- Isolation of an HLA‐A2.1 extracted human minor histocompatibility peptideEuropean Journal of Immunology, 1993
- Do unconventional myosins exert functions in dynamics of membrane compartments?FEBS Letters, 1992
- Characterization of Peptides Bound to the Class I MHC Molecule HLA-A2.1 by Mass SpectrometryScience, 1992
- Allele-specific motifs revealed by sequencing of self-peptides eluted from MHC moleculesNature, 1991
- EFFECTOR MECHANISMS IN GRAFT-VERSUS-HOST DISEASE IN RESPONSE TO MINOR HISTOCOMPATIBILITY ANTIGENSTransplantation, 1990
- A minor transplantation antigen detected by MHC-restricted cytotoxic T lymphocytes during graft-versus-host diseaseNature, 1983