Similar long‐term results of breast‐conservation treatment for Stage I and II invasive lobular carcinoma compared with invasive ductal carcinoma of the breast
Open Access
- 2 June 2005
- Vol. 103 (12), 2447-2454
- https://doi.org/10.1002/cncr.21071
Abstract
BACKGROUND The objective of the current study was to determine the long-term results of breast-conservation treatment in women with early-stage, invasive lobular carcinoma of the breast. METHODS Between 1977 and 1995, 1093 women with Stage I and II invasive ductal carcinoma of the breast and 55 women with invasive lobular carcinoma of the breast underwent lumpectomy, axillary lymph node dissection, and radiation treatment. Overall, 49% of the women received adjuvant systemic therapy (chemotherapy and/or hormones). RESULTS The median age was 52 years for patients in the invasive ductal group and 54 years for patients in the invasive lobular group. The median follow-up was 8.7 years and 10.2 years for patients in the invasive ductal and invasive lobular groups, respectively. A comparison of patients who had invasive lobular carcinoma with patients who had invasive ductal carcinoma showed no difference in the 10-year actuarial rates of overall survival (85% vs. 79%, respectively; P = 0.73), cause-specific survival (93% vs. 84%, respectively; P = 0.85), or freedom from distant metastases (81% vs. 80%, respectively; P = 0.76). The 10-year rates of local failure were 18% for patients with invasive lobular carcinoma and 12% for patients with invasive ductal carcinoma (P = 0.24), and the 10-year rates of contralateral breast carcinoma development for the 2 groups were 12% and 8%, respectively (P = 0.40). CONCLUSIONS Breast-conservation treatment yielded similar long-term results for women with early-stage, invasive lobular carcinoma and women with the more prevalent invasive ductal carcinoma. Cancer 2005. © 2005 American Cancer Society.Keywords
This publication has 38 references indexed in Scilit:
- Presalvage prostate‐specific antigen (PSA) and PSA doubling time as predictors of biochemical failure of salvage cryotherapy in patients with locally recurrent prostate cancer after radiotherapyCancer, 2006
- Twenty-Year Follow-up of a Randomized Study Comparing Breast-Conserving Surgery with Radical Mastectomy for Early Breast CancerNew England Journal of Medicine, 2002
- Conservative surgery for infiltrating lobular breast carcinomaBritish Journal of Surgery, 1997
- Conservative surgery for infiltrating lobular breast carcinomaBritish Journal of Surgery, 1997
- Tumor Biology of Infiltrating Lobular CarcinomaAnnals of Surgery, 1995
- Conservative surgery and radiation therapy for infiltrating lobular carcinoma of the breast: The role of preoperative mammograms in guiding treatmentCancer, 1994
- Infiltrating lobular carcinoma. Is it different from infiltrating duct carcinoma?Cancer, 1994
- Conservation therapy for invasive lobular carcinoma of the breastCancer, 1992
- Influence of infiltrating lobular histology on local tumor control in breast cancer patients treated with conservative surgery and radiotherapyCancer, 1989
- Nonparametric Estimation from Incomplete ObservationsJournal of the American Statistical Association, 1958