Pharmacokinetics and Pharmacodynamics of Hydroxyurea
- 1 January 1998
- journal article
- review article
- Published by Springer Science and Business Media LLC in Clinical Pharmacokinetics
- Vol. 34 (5), 347-358
- https://doi.org/10.2165/00003088-199834050-00002
Abstract
Hydroxyurea is used in the treatment of various forms of cancer, sickle-cell anaemia and HIV infection. Oral absorption of the drug is virtually complete, the volume of distribution is equivalent to total body water and elimination is through both renal and nonrenal mechanisms. Nonrenal elimination of hydroxyurea is characterised by Michaelis-Menten kinetics. Further studies are necessary to clarify several aspects of the pharmacokinetics and pharmacodynamics of hydroxyurea: the effect of age and disease state, concentration-effect relationship, the role of therapeutic drug monitoring, and the mechanisms of renal and nonrenal elimination. The recent development of improved assays for hydroxyurea should have benefits for future pharmacokinetic studies.Keywords
This publication has 68 references indexed in Scilit:
- Hydroxyurea Treatment in HIV-Infected PatientsJAIDS Journal of Acquired Immune Deficiency Syndromes, 1996
- Pharmacokinetics of Hydroxyurea in Patients Infected with Human Immunodeficiency Virus Type IThe Journal of Clinical Pharmacology, 1996
- Pharmacokinetics of hydroxyurea in nude miceAnti-Cancer Drugs, 1994
- Regulation and drug resistance mechanisms of mammalian ribonucleotide reductase, and the significance to DNA synthesisBiochemistry and Cell Biology, 1990
- Hydroxyurea and Etoposide: In Vitro Synergy and Phase I Clinical TrialJNCI Journal of the National Cancer Institute, 1988
- Evidence that the antitumor agent hydroxyurea enters mammalian cells by a diffusion mechanismBiochemical and Biophysical Research Communications, 1986
- Evidence for the involvement of cytochrome P-450-dependent monooxygenase(s) in the formation of genotoxic metabolites from N-hydroxyureaBiochemical and Biophysical Research Communications, 1984
- A Pilot Study of Hydroxyurea in Hormone “Escaped” Metastatic Carcinoma of the ProstateBritish Journal of Urology, 1982
- Comparative distribution and embryotoxicity of hydroxyurea in pregnant rats and rhesus monkeysTeratology, 1975
- Hydroxyurea therapy in chronic myelogenous leukemiaCancer, 1972