Within-person variance in biochemical indicators of iron status: effects on prevalence estimates
Open Access
- 1 September 1990
- journal article
- research article
- Published by Elsevier BV in The American Journal of Clinical Nutrition
- Vol. 52 (3), 541-547
- https://doi.org/10.1093/ajcn/52.3.541
Abstract
The effect of within-person variance on prevalence estimates from population distributions based on a single measurement was examined for hematologic and iron-status indicators collected in the Hispanic Health and Nutrition Examination Survey (HHANES). Within-person to between-person variance ratios (W:Bs) were estimated for 11 indicators by using data from 80 persons who provided blood twice in HHANES. Distributions of selected iron-status indicators from 20–44-y-old Mexican American females from HHANES were adjusted for within-person variance by using the W:B estimates, and prevalences of low values based on the original and adjusted distributions were compared. W:B were less than 1 for the majority of the indicators. Nonetheless, prevalences of low values from the original distributions were inflated when commonly used cutoff values were applied. Within-person variance in serum analytes needs to be controlled when the prevalence of a condition in populations is assessed.Keywords
This publication has 13 references indexed in Scilit:
- Prevalence of Hemochromatosis among 11,065 Presumably Healthy Blood DonorsNew England Journal of Medicine, 1988
- Intra- and interindividual variation in measurements of beta-carotene, retinol, and tocopherols in diet and plasmaThe American Journal of Clinical Nutrition, 1987
- EFFECTS OF INTRAINDIVIDUAL AND INTERINDIVIDUAL VARIATION IN REPEATED DIETARY RECORDSAmerican Journal of Epidemiology, 1985
- Statistical methods to assess and minimize the role of intra-individual variability in obscuring the relationship between dietary lipids and serum cholesterolJournal of Chronic Diseases, 1978
- Relationship of Day-to-day Variation of Serum Iron Concentrations to Iron-binding Capacity in Healthy Young WomenAmerican Journal of Clinical Pathology, 1977
- Variation of serum iron concentration in young healthy men: within-day and day-to-day changesClinical Biochemistry, 1976
- Studies in lead poisoningBiochemical Medicine, 1973
- Daily Variation in the Concentration of Iron in SerumAmerican Journal of Clinical Pathology, 1963
- The determination of the total iron-binding capacity of serumClinica Chimica Acta; International Journal of Clinical Chemistry, 1957
- Diurnal Variation in the Plasma Iron Level of Man.Experimental Biology and Medicine, 1950