A Review on Hematological Factors in Opioid-Dependent People (Opium and Heroin) after the Withdrawal Period
Open Access
- 1 January 2010
- journal article
- Vol. 2, 9-16
Abstract
Long-term use of opioids has acute effects on homeostasis of the body. Discovering the impacts of opioids on hematological parameters of narcotics withdrawal and dependents blood may be helpful in recognizing the homeostasis condition of their body for the useful treatment. In this study a cross-sectional method was applied. The abusers of opium and heroin for more than two consecutive years were considered as opium and heroin dependent groups, respectively. The dependent people, who passed the 1-month withdrawal period, entered the study as opium and heroin withdrawal groups. In this study, hematological factors of heroin and opium dependent and withdrawal groups were investigated. The RBC count remained unchanged in all groups. The WBC count had a significant increase in opium dependent group but in heroin dependent group and withdrawal group there was no significant difference. HGB level had a significant increase only in opium and heroin withdrawal groups. The percentage of HCT had a significant increase in all groups. The MCV increased in heroin and opium dependent groups. MCH level increased significantly in heroin and opium withdrawal groups. MCHC level had a significant increase in all groups. Neutrophil and lymphocyte counts in heroin and opium addicted groups significantly decreased. Platelet, neutrophil and monocyte counts significantly increased in opium dependent group. Monocyte countshowed a significant reduction in heroin withdrawal group. Eosinophil count showed no difference in any of the groups. The current study indicated that not only the chronic and long-term use of opium and heroin, also withdrawal of addicted people could change hematological parameters related to human serum.Keywords
This publication has 38 references indexed in Scilit:
- Drugs and development: The global impact of drug use and trafficking on social and economic developmentInternational Journal of Drug Policy, 2008
- Electrophoretic Profile of Serum Proteins in Opium and Heroin DependentsThe American Journal of Drug and Alcohol Abuse, 2008
- Opioid Therapy and ImmunosuppressionClinical Journal of Sport Medicine, 2004
- Microbial Infections, Immunomodulation, and Drugs of AbuseClinical Microbiology Reviews, 2003
- Stress-Induced Suppression of the Immune System after Withdrawal from Chronic CocaineThe Journal of pharmacology and experimental therapeutics, 2003
- Opioids, opioid receptors, and the immune responseDrug and Alcohol Dependence, 2001
- Alterations of immune functions in heroin addicts and heroin withdrawal subjects.1998
- Chronic morphine treatment selectively suppresses macrophage colony formation in bone marrowEuropean Journal of Pharmacology, 1991
- Alteration of T and null lymphocyte frequencies in the peripheral blood of human opiate addicts: in vivo evidence for opiate receptor sites on T lymphocytes.The Journal of Immunology, 1980
- The susceptibility to moniliasis in children with endocrine hypofunction.1967