Different Responses of Macrophages to Smooth and RoughBrucellaspp.: Relationship to Virulence
Open Access
- 1 April 2004
- journal article
- Published by American Society for Microbiology in Infection and Immunity
- Vol. 72 (4), 2429-2433
- https://doi.org/10.1128/iai.72.4.2429-2433.2004
Abstract
By comparing smooth wild-typeBrucellastrains to their rough mutants, we show that the lipopolysaccharide (LPS) O side chain of pathogenicBrucellahas a dramatic impact on macrophage activation. It favors the development of virulentBrucellaby preventing the synthesis of immune mediators, important for host defense. We conclude that this O chain property is firmly linked toBrucellavirulence.Keywords
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