Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions
Top Cited Papers
- 16 November 2011
- journal article
- review article
- Published by Springer Science and Business Media LLC in Nature Reviews Molecular Cell Biology
- Vol. 12 (12), 773-786
- https://doi.org/10.1038/nrm3227
Abstract
Half a century of biochemical and biophysical experiments has provided attractive models that may explain the diverse functions of microtubules within cells and organisms. However, the notion of functionally distinct microtubule types has not been explored with similar intensity, mostly because mechanisms for generating divergent microtubule species were not yet known. Cells generate distinct microtubule subtypes through expression of different tubulin isotypes and through post- translational modifications, such as detyrosination and further cleavage to Delta 2-tubulin, acetylation, polyglutamylation and polyglycylation. The recent discovery of enzymes responsible for many tubulin post- translational modifications has enabled functional studies demonstrating that these post- translational modifications may regulate microtubule functions through an amazing range of mechanisms.Keywords
This publication has 189 references indexed in Scilit:
- Structural Basis of the 9-Fold Symmetry of CentriolesCell, 2011
- Tubulin post-translational modifications: encoding functions on the neuronal microtubule cytoskeletonTrends in Neurosciences, 2010
- Myc-Nick: A Cytoplasmic Cleavage Product of Myc that Promotes α-Tubulin Acetylation and Cell DifferentiationCell, 2010
- Tubulin Glutamylation Regulates Ciliary Motility by Altering Inner Dynein Arm ActivityCurrent Biology, 2010
- Microtubule-severing enzymesCurrent Opinion in Cell Biology, 2010
- Human TUBB3 Mutations Perturb Microtubule Dynamics, Kinesin Interactions, and Axon GuidanceCell, 2010
- Axoneme β-Tubulin Sequence Determines Attachment of Outer Dynein ArmsCurrent Biology, 2008
- Polyglutamylation: a fine‐regulator of protein function?EMBO Reports, 2008
- TTLL10 is a protein polyglycylase that can modify nucleosome assembly protein 1FEBS Letters, 2008
- Origin and Evolution of the CentrosomeAdvances in experimental medicine and biology, 2006