The effects of occupational lead exposure on selected inflammatory biomarkers
Open Access
- 1 March 2019
- journal article
- research article
- Published by Walter de Gruyter GmbH in Archives of Industrial Hygiene and Toxicology
- Vol. 70 (1), 36-41
- https://doi.org/10.2478/aiht-2019-70-3214
Abstract
In exposure to toxic metals such as lead, determining lead and cytokine levels (IL-6, IL-10, and TNF-α) is essential for early detection of diseases. The aim of this study was to develop an model for early detection of inflammation and onset of atherosclerosis in the absence of clinical findings in young workers, which could help physicians take timely an action and start treatment. This study included 49 metal workers exposed to lead occupationally and 50 unexposed administrative workers (controls) who underwent immunological analysis for cytokines (IL-6, IL-10, and TNF-α) and atherosclerosis markers (h-FABP and VCAM-1), toxicological analysis for lead, and routine biochemical analysis (ALT, AST, creatinine) at the Ankara Occupational and Environmental Diseases Hospital in 2017. Lead levels correlated with IL-6, IL-10, and TNF-α (r=0.469, r=0.521 and r=0.279, respectively, p<0.01) but did not significantly affect h-FABP and VCAM-1 levels.Keywords
This publication has 34 references indexed in Scilit:
- Increased H-FABP concentrations in nonalcoholic fatty liver diseaseHerz, 2013
- Effect of GST polymorphisms on As levels of placental and maternal biological samplesToxicology Letters, 2012
- A2 Adenosine Receptors and Vascular PathologiesArteriosclerosis, Thrombosis, and Vascular Biology, 2012
- Heart-Type Fatty Acid Binding Protein (H-FABP): Relationship with arterial ıntima-media thickness and role as diagnostic marker for atherosclerosis in patients with ımpaired glucose metabolismCardiovascular Diabetology, 2011
- Inflammation in Atherosclerosis From Pathophysiology to PracticeJournal of the American College of Cardiology, 2009
- 18F-4V for PET–CT Imaging of VCAM-1 Expression in AtherosclerosisJACC: Cardiovascular Imaging, 2009
- Lead Exposure and Cardiovascular Disease—A Systematic ReviewEnvironmental Health Perspectives, 2007
- Clinical Evaluation of Point‐of‐Care‐Testing of Heart‐Type Fatty Acid‐Binding Protein (H‐FABP) for the Diagnosis of Acute Myocardial InfarctionJournal of Immunoassay and Immunochemistry, 2006
- Cytokines in Atherosclerosis: Pathogenic and Regulatory PathwaysPhysiological Reviews, 2006
- The multigene family of fatty acid-binding proteins (FABPs): Function, structure and polymorphismJournal of Applied Genetics, 2006