Multilevel Research and the Challenges of Implementing Genomic Medicine
Open Access
- 1 May 2012
- journal article
- research article
- Published by Oxford University Press (OUP) in JNCI Monographs
- Vol. 2012 (44), 112-120
- https://doi.org/10.1093/jncimonographs/lgs003
Abstract
Advances in genomics and related fields promise a new era of personalized medicine in the cancer care continuum. Nevertheless, there are fundamental challenges in integrating genomic medicine into cancer practice. We explore how multilevel research can contribute to implementation of genomic medicine. We first review the rapidly developing scientific discoveries in this field and the paucity of current applications that are ready for implementation in clinical and public health programs. We then define a multidisciplinary translational research agenda for successful integration of genomic medicine into policy and practice and consider challenges for successful implementation. We illustrate the agenda using the example of Lynch syndrome testing in newly diagnosed cases of colorectal cancer and cascade testing in relatives. We synthesize existing information in a framework for future multilevel research for integrating genomic medicine into the cancer care continuum.Keywords
This publication has 93 references indexed in Scilit:
- State-of-the-Art and Future Directions in Multilevel Interventions Across the Cancer Control ContinuumJNCI Monographs, 2012
- Multilevel Factors Affecting Quality: Examples From the Cancer Care ContinuumJNCI Monographs, 2012
- Clinically Relevant Changes in Family History of Cancer Over TimeJama-Journal Of The American Medical Association, 2011
- Genomics and Drug ResponseNew England Journal of Medicine, 2011
- Performance of Common Genetic Variants in Breast-Cancer Risk ModelsNew England Journal of Medicine, 2010
- Interventions to Increase Recommendation and Delivery of Screening for Breast, Cervical, and Colorectal Cancers by Healthcare Providers: Systematic Reviews of Provider Assessment and Feedback and Provider IncentivesAmerican Journal of Preventive Medicine, 2008
- Heterogeneity in cancer guidelines: should we eradicate or tolerate?Annals of Oncology, 2008
- Electronic Health Records in Ambulatory Care — A National Survey of PhysiciansNew England Journal of Medicine, 2008
- Targeting the function of the HER2 oncogene in human cancer therapeuticsOncogene, 2007
- Why Don't Physicians Follow Clinical Practice Guidelines?Jama-Journal Of The American Medical Association, 1999