The study of aberrant methylation in cancer via restriction landmark genomic scanning
- 5 August 2002
- journal article
- review article
- Published by Springer Science and Business Media LLC in Oncogene
- Vol. 21 (35), 5414-5426
- https://doi.org/10.1038/sj.onc.1205608
Abstract
Restriction landmark genomic scanning (RLGS) has been used to study DNA methylation in cancer for nearly a decade. The strong bias of RLGS for assessing the methylation state of CpG islands genome wide makes this an attractive technique to study both hypo- and hypermethylation of regions of the genome likely to harbor genes. RLGS has been used successfully to identify regions of hypomethylation, candidate tumor suppressor genes, correlations between hypermethylation events and clinical factors, and quantification of hypermethylation in a multitude of malignancies. This review will examine the major uses of RLGS in the study of aberrant methylation in cancer and discuss the significance of some of the findings. Oncogene (2002) 21, 5414-5426. doi:10.1038/sj.onc. 1205608This publication has 85 references indexed in Scilit:
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