Diabetes, Obesity, and the Brain
Top Cited Papers
- 21 January 2005
- journal article
- special viewpoints
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 307 (5708), 375-379
- https://doi.org/10.1126/science.1104344
Abstract
Recent evidence suggests a key role for the brain in the control of both body fat content and glucose metabolism. Neuronal systems that regulate energy intake, energy expenditure, and endogenous glucose production sense and respond to input from hormonal and nutrient-related signals that convey information regarding both body energy stores and current energy availability. In response to this input, adaptive changes occur that promote energy homeostasis and the maintenance of blood glucose levels in the normal range. Defects in this control system are implicated in the link between obesity and type 2 diabetes.Keywords
This publication has 48 references indexed in Scilit:
- C75, a Fatty Acid Synthase Inhibitor, Reduces Food Intake via Hypothalamic AMP-activated Protein KinaseOnline Journal of Public Health Informatics, 2004
- AMP-kinase regulates food intake by responding to hormonal and nutrient signals in the hypothalamusNature, 2004
- Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophyJournal of Medical Genetics, 2002
- Decreasing hypothalamic insulin receptors causes hyperphagia and insulin resistance in ratsNature Neuroscience, 2002
- Leptin-Replacement Therapy for LipodystrophyThe New England Journal of Medicine, 2002
- From lipodystrophy syndromes to diabetes mellitusThe Lancet, 2001
- Lipoatrophy RevisitedTrends in Endocrinology & Metabolism, 2000
- The Central Melanocortin System and Energy HomeostasisTrends in Endocrinology & Metabolism, 1999
- Intracerebroventricular Neuropeptide Y Acutely Influences Glucose Metabolism and Insulin Sensitivity in the RatJournal of Neuroendocrinology, 1997
- Chronic intracerebroventricular infusion of insulin reduces food intake and body weight of baboonsNature, 1979