Effect of Muscle Denervation on Growth of Transplanted Tumor in Mice
- 1 November 1970
- journal article
- Published by Proceedings of the National Academy of Sciences in Proceedings of the National Academy of Sciences of the United States of America
- Vol. 67 (3), 1521-1527
- https://doi.org/10.1073/pnas.67.3.1521
Abstract
A temporary retardation of transplanted Round Cell Neuroblastoma growth in the gastrocnemius muscle of mice was observed in 20% of the animals after denervation of the muscle. The tumor cells in these denervated animals showed structural alterations and deterioration in function. These altered cells when mixed with associated denervated muscle tissue, to which was added fresh tumor, produced a higher percentage of retardation upon subsequent transplants in innervated muscle.Keywords
This publication has 11 references indexed in Scilit:
- PRELIMINARY STUDIES IN ANIMALS CONCERNING THE RELATIONSHIP BETWEEN THE NERVOUS SYSTEM AND CANCER*Annals of the New York Academy of Sciences, 2006
- ON THE PSYCHOPHYSIOLOGICAL MECHANISM OF THE ORGANISM'S RESISTANCE TO TUMOR GROWTHAnnals of the New York Academy of Sciences, 2006
- Dynamics of growth in tumors and in normal organisms.1969
- Impaired skeletal muscle maturation following neonatal neurectomyDevelopmental Biology, 1968
- HISTOCHEMISTRY AND CYTOCHEMISTRY OF EXPERIMENTALLY DENERVATED GUINEA PIG MUSCLE. I.Cells Tissues Organs, 1965
- Long-Term Tissue Culture of Neuroblastomas. II. Morphologic Evidence for Differentiation and Maturation2JNCI Journal of the National Cancer Institute, 1964
- Influence of host factors on the growth of neoplastic cells.1963
- Phosphorylase Activity in Denervated Skeletal Muscle.Experimental Biology and Medicine, 1961
- Psychological States as Factors in the Development of Malignant Disease: A Critical Review2JNCI Journal of the National Cancer Institute, 1959
- Gastric Cancer Experimentally Induced in Insects by Nerve Severance1JNCI Journal of the National Cancer Institute, 1949