SURGICAL APPLICATIONS OF CYANOACRYLATE ADHESIVES: A REVIEW OF TOXICITY
- 27 March 2007
- journal article
- review article
- Published by Wiley in Anz Journal of Surgery
- Vol. 77 (4), 209-213
- https://doi.org/10.1111/j.1445-2197.2007.04020.x
Abstract
Cyanoacrylate (CA) and its homologues have a variety of medical and commercial applications as biological adhesives and sealants. Homologues of CA are being widely promoted in surgery as a tissue adhesive to replace traditional suturing techniques. Potential benefits of using CA adhesives include better cosmetic results, more rapid wound closure, and perhaps most significantly, the potential for significant reductions in percutaneous injuries from suture needles, which would in turn also reduce the risk of transmission of infectious diseases. Nevertheless, certain concerns have been raised regarding the potential toxicity of CA within patients, as well as among health professionals who are occupationally exposed when using CA compounds. Reported toxicity of CA in the workplace may result in dermatological, allergic and respiratory conditions. To help reduce the occupational burden, therefore, medical staff using CA adhesives should avoid direct contact with the compound and use appropriate personal protective measures at all times. Maintaining higher levels of humidity, optimizing room ventilation and using special air conditioning filters in surgical suites and operating theatres may also be useful in minimizing the exposure to volatile CA adhesivesKeywords
This publication has 48 references indexed in Scilit:
- Toxicity of Cyanoacrylate Adhesives and Their Occupational Impacts for Dental Staff.Industrial Health, 2004
- EPIDEMIOLOGIC STUDY OF PULMONARY OBSTRUCTION IN WORKERS OCCUPATIONALLY EXPOSED TO ETHYL AND METHYL CYANOACRYLATEJournal of Toxicology and Environmental Health, Part A, 2000
- Occupational allergic contact dermatitis from cyanoacrylateDermatitis®, 1998
- Histopathological changes following the use of biological and synthetic glue for dural grafts: an experimental studyBritish Journal of Neurosurgery, 1998
- Lip suture with isobutyl cyanoacrylateDental Traumatology, 1994
- Toxicity of cyanoacrylates in vitro using extract dilution assay on cell culturesBiomaterials, 1994
- The use of tissue adhesion for traumatic laceration repair in the emergency departmentAnnals of Emergency Medicine, 1993
- In vitro toxicity test of 2‐cyanoacrylate polymers by cell culture methodJournal of Biomedical Materials Research, 1990
- Increased eytotoxicity of nanoparticle-carried Adriamycin in vitro and potentiation by verapamil and amiodaroneBiomaterials, 1989
- Cytotoxicity of alkyl‐2‐cyanoacrylate adhesivesJournal of Biomedical Materials Research, 1989