Chronic systemic pesticide exposure reproduces features of Parkinson's disease
- 1 December 2000
- journal article
- research article
- Published by Springer Science and Business Media LLC in Nature Neuroscience
- Vol. 3 (12), 1301-1306
- https://doi.org/10.1038/81834
Abstract
The cause of Parkinson's disease (PD) is unknown, but epidemiological studies suggest an association with pesticides and other environmental toxins, and biochemical studies implicate a systemic defect in mitochondrial complex I. We report that chronic, systemic inhibition of complex I by the lipophilic pesticide, rotenone, causes highly selective nigrostriatal dopaminergic degeneration that is associated behaviorally with hypokinesia and rigidity. Nigral neurons in rotenone-treated rats accumulate fibrillar cytoplasmic inclusions that contain ubiquitin and α-synuclein. These results indicate that chronic exposure to a common pesticide can reproduce the anatomical, neurochemical, behavioral and neuropathological features of PD.This publication has 37 references indexed in Scilit:
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