Induction of Calcium Influx in Cortical Neural Networks by Nanomagnetic Forces
- 31 January 2016
- journal article
- research article
- Published by American Chemical Society (ACS) in ACS Nano
- Vol. 10 (2), 2331-2341
- https://doi.org/10.1021/acsnano.5b07118
Abstract
Nanomagnetic force stimulation with ferromagnetic nanoparticles was found to trigger calcium influx in cortical neural networks without observable cytotoxicity. Stimulated neural networks showed an average of 20% increment in calcium fluorescence signals and a heightened frequency in calcium spiking. These effects were also confined spatially to areas with engineered high magnetic field gradients. Furthermore, blockage of N-type calcium channels inhibited the stimulatory effects of the nanomagnetic forces, suggesting the role of mechano-sensitive ion channels in mediating calcium influx.Funding Information
- National Cancer Institute (P30 CA016042)
- National Center for Research Resources (1S10RR23057, CJX1-443835-WS-29646)
- NIH Office of the Director (1DP2OD007113)
- National Institute of Allergy and Infectious Diseases (5P30 AI028697)
- Swiss National Science Foundation (P3002P2_147753)
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