Screening Extended Families for Genetic Hemoglobin Disorders in Pakistan
Open Access
- 10 October 2002
- journal article
- research article
- Published by Massachusetts Medical Society in New England Journal of Medicine
- Vol. 347 (15), 1162-1168
- https://doi.org/10.1056/nejmsa013234
Abstract
We have investigated a strategy for identifying and counseling carriers of recessively inherited disorders in developing countries where consanguineous marriage is common. In such communities, gene variants are trapped within extended families, so that an affected child is a marker of a group at high genetic risk.Keywords
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