Antidiabetic Activities of Chalcones Isolated from a Japanese Herb, Angelica keiskei
- 21 June 2007
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Agricultural and Food Chemistry
- Vol. 55 (15), 6013-6017
- https://doi.org/10.1021/jf070720q
Abstract
Diabetes mellitus is a chronic disease that is characterized by hyperglycemia caused by insufficient insulin action. We have explored the edible ingredients from folk medicines in Japan that contain substances complementing insulin action, such as the induction of adipocyte differentiation and the enhancement of glucose uptake. We eventually found that the ethanol extract from a Japanese herb “Ashitaba”, Angelica keiskei, contained two major chalcones of 4-hydroxyderricin (4-HD) and xanthoangelol that showed strong insulin-like activities via a pathway independent of the peroxisome proliferator-activated receptor-γ activation. The 4-HD especially showed the preventive effects on the progression of diabetes in genetically diabetic KK-Ay mice. Keywords: Diabetes; insulin-like; adipocyte differentiation; glucose-uptake; chalcone; Angelica keiskei; 4-hydroxyderricin; xanthoangelol; PPAR-γThis publication has 9 references indexed in Scilit:
- Cinnamon water extracts increase glucose uptake but inhibit adiponectin secretion in 3T3-L1 adipose cellsMolecular Nutrition & Food Research, 2006
- Antitumor and antimetastatic activities of Angelica keiskei roots, part 1: Isolation of an active substance, xanthoangelolInternational Journal of Cancer, 2003
- Peroxisome Proliferator-activated Receptor γ (PPARγ) as a Molecular Target for the Soy Phytoestrogen GenisteinOnline Journal of Public Health Informatics, 2003
- Insulin signalling and the regulation of glucose and lipid metabolismNature, 2001
- Global and societal implications of the diabetes epidemicNature, 2001
- Roles of Phosphorylation Sites in Regulating Activity of the Transcription Factor Pho4Science, 1999
- Troglitazone increases the number of small adipocytes without the change of white adipose tissue mass in obese Zucker rats.JCI Insight, 1998
- Anti-Tumor-Promotion by Principles Obtained fromAngelica keiskeiPlanta Medica, 1991
- The structure of xanthoangelol, a new chalcone from the roots of Angelica keiskei Koidzumi (Umbelliferae).CHEMICAL & PHARMACEUTICAL BULLETIN, 1977